Great Deluge Algorithm for Protein Structure Prediction

Proteins are the basis of organic life on the Earth. These macromolecules appear as polymer chains comprising ∼70 to more than 500 residues (amino acids) of 20 different monomer types. In nature such chains fold into certain 3-dimensional structures (see example in Fig.1). The distinct property of proteins (which distinguishes them from other polymers) is that all molecules with the same order of residues fold into the same structure (so-called native state conformation). There is a general hypothesis that in the native state all interatomic forces are balanced and a molecule has the minimum possible internal energy.